A Pilot Trial of Nicotinamide Riboside and Coenzyme Q10 on Inflammation and Oxidative Stress in Chronic Kidney Disease

Objective

To investigate the effects of NR and CoQ10 on oxidative stress, inflammation, and mitochondrial function in patients with chronic kidney disease (CKD).

Study Design

Randomized double-blind, placebo-controlled, crossover study in 25 chronic kidney disease CKD patients

Dose

1000 mg of NR or 1200 mg of CoQ10

Duration

6 weeks

Key Outcomes

  • NR supplementation primarily affected gene activity related to carbohydrate/fat metabolism and immune signaling, while CoQ10 influenced genes linked to immune/stress response and fat metabolism.

  • Both NR and CoQ10 reduced plasma oxidative stress markers, but their effects on inflammation markers differed. NR showed mixed results, whereas CoQ10 consistently reduced inflammation.

  • Only NR improved mitochondrial function in monocytes.

Clinical, Metabolic HealthANAD Staff