Implications of NAD + boosters in translational medicine

Baeki E Kang, Jun-Yong Choi, Sokrates Stein, Dongryeol Ryu

Abstract

Nicotinamide adenine dinucleotide (NAD+ ) is an essential metabolite in energy metabolism as well as a co-substrate in biochemical reactions such as protein deacylation, protein ADP-ribosylation, and cyclic ADP-ribose synthesis mediated by sirtuins, poly ADP-ribose polymerases (PARPs), and CD38. In eukaryotic cells, NAD+ is synthesized through three distinct pathways, which offer different strategies to modulate the bioavailability of NAD+ . The therapeutic potential of dietarily available NAD+ boosters preserving the NAD+ pool has been attracting attention after the discovery of declining NAD+ levels in aging model organisms as well as in several age-related diseases, including cardiometabolic and neurodegenerative diseases. Here, we review the recent advances in the biology of NAD+ , including the salubrious effects of NAD+ boosters and discuss their future translational strategies.

JOURNAL

European Journal of Clinical Investigation