Nicotinamide Riboside Improves Muscle Mitochondrial Biogenesis, Satellite Cell Differentiation, and Gut Microbiota in a Twin Study

Objective

To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. 

Study Design

Nonrandomized, open-label, parallel-assignment study in 20 BMI-discordant (one leaner, one heavier) identical twin pairs

Dose

1000 mg

Duration

5 months

Key Outcomes

  • In the BMI-discordant twin pairs, NR supplementation was well-tolerated and increased whole blood NAD+ levels.

  • NR also increased muscle mitochondrial biogenesis and improved gut microbiota composition, as seen through an increase in the abundance of Faecalibacterium prausnitzii—one of the most beneficial bacteria found in the microbiome of healthy humans.

Clinical, Muscle HealthANAD StaffMuscle Health