Nicotinamide Riboside Augments Human Macrophage Migration via SIRT3-Mediated Prostaglandin E2 Signaling

Objective

To investigate how NR influences the migration of macrophages and the underlying mechanisms behind this effect.

Study Design

Ex Vivo:
Monocytes were extracted from young, healthy subjects and then treated with NR

In Vivo:
Randomized, double-blind, placebo-controlled, pilot study in 36 young, healthy subjects

Dose

1000 mg

Duration

1 week

Key Outcomes

Ex Vivo:

  • NR treatment increased levels of NAD+ and prostaglandin E2 (PGE2), a key regulator of inflammatory and immune responses, in monocytes from healthy subjects.

In Vivo:

  • NR supplementation increased PGE2 levels in human serum.

Clinical, Inflammation/Immune HealthANAD Staff