Acute Nicotinamide Riboside Supplementation Increases Human Cerebral NAD+ Levels In Vivo

Objective

To investigate the effects of acute NR supplementation on cerebral NAD+ levels in the healthy human brain using a specialized MRI technique called downfield proton magnetic resonance spectroscopy (DF1H MRS).

Study Design

Open-label, pilot study in 10 healthy subjects

Dose

900 mg

Duration

4 hours

Key Outcomes

  • NR supplementation significantly increased brain NAD+ levels by about 16% compared to baseline.

Clinical, Neurological HealthANAD Staff