Nicotinamide Riboside Restores Bone Health in Glucocorticoid-Induced Osteoporosis: Preclinical Findings

Synopsis Glucocorticoid-induced osteoporosis (GIOP) is a major side effect of long-term steroid use, caused by damage to osteoblasts—the bone-forming cells. Recent studies show that ferroptosis, a...

Nicotinamide Riboside Protects Bones via Mitochondrial Support: Preclinical Findings

Synopsis This study uncovered how gut microbiota imbalances contribute to osteoporosis through the overproduction of trimethylamine-N-oxide (TMAO), a metabolite formed from L-carnitine by intestin...

Nicotinamide Riboside Restores NAD+ and Prevents Age-Related Bone Loss: Preclinical Findings

SynopsisAge-related osteoporosis happens because of a decline in osteoblasts—the cells that build bone—and fewer osteoblast progenitor cells, which show signs of aging called senescence. FoxO trans...