What We Need to Know About Each of the Vitamin B3s
NR is a Next-Generation Form of Vitamin B3
While each of these very similar sounding compounds all belong to the vitamin B3 family, each molecule is structurally unique, and therefore processed in different ways by the body. These differences contribute to the varying effectiveness of each in supporting different aspects of our health.
Pre-clinical studies have proven that there are significant differences in each of the B3 molecule’s ability to effectively support our body’s longevity promoting mechanisms, as well as cellular energy production. Research suggests nicotinamide riboside is the most efficient and effective form of vitamin B3 at boosting NAD levels.7
1. Bieganowski, P. & Brenner, C. (2004). Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 117, 495-502.
2. Trammel, S. A., Yu, L., Migaud, M.E., Brenner, C.(2016). Nicotinamide riboside is a major NAD+ precursor vitamin in cow milk. Journal of Nutrition, 146(5), 957–63.
3. Chi Y & Suave AA (2013) Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Current Opinion in Clin. Nutr. and Metab. Care 16, 657-661.
4. Wylde, B. (2016, October 12). Published studies reveal how a superior form of vitamin B3 called NR may play an important role in helping us enjoy longer, healthier lives – Diet & Nutrition Info and Tips. Retrieved November 02, 2016, from http://www.empowher.com/community/share/published-studies-reveal-how-superior-form-vitamin-b3-called-nr-may-play-im
5. Linus Pauling Institute – Micronutrient Information Center. Niacin. Retrieved October, 2016. http://lpi.oregonstate.edu/mic/vitamins/niacin
6. Higdon, J., PhD., V. J. Drake PhD, B. Delage PhD. Linus Pauling Institute – Micronutrient Information Center. Niacin, Retrieved August, 2016, from http://lpi.oregonstate.edu/mic/vitamins/niacin
7. Trammell, S. A., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Abel, E.D., Migaud, M.E., Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7, 12948. doi:10.1038/ncomms12948