Benefits of NR

As the most efficient and effective vitamin B3 at increasing NAD, NR can deliver results in a number of different areas:


  • Promotes healthy mitochondrial function, which is an important component of human aging2
  • Supplementation of an NAD+ precursor for one week in aged mice reversed their mitochondrial dysfunction and returned mitochondrial health and key biochemical markers of muscle health to levels similar to a young mouse1,2
  • Increases sirtuin activation, improving mitochondrial activity to help prevent cellular damage due to free radicals2,3


Shown to lower high-fat-diet-induced weight gain by enhancing energy metabolism1,3

Cardiovascular Health

Promotes beneficial effects on blood lipids by maintaining healthy cholesterol levels already within normal range3


  • Maintains neuronal health
  • Improves cognitive function and protects against axonal degeneration associated with aging1,2


  • Improved endurance due to enhanced mitochondrial function2
  • More robust respiratory exchange ratio (RER) between feeding and fasting periods1
Charles Brenner, PhD.
Charles Brenner, PhD.Roy J. Carver, Chair and Head of Biochemistry; University of Iowa; The discoverer of NR as a vitamin, Dr. Brenner is the world's leading expert on NAD metabolism. He has published more than 35 articles in scientific literature on actions of NR and NAD metabolism.

“We obtained convincing evidence that oral supplementation of NR boosts NAD and enhances the body’s utilization of NAD to a greater degree than the conventional forms of vitamin B3. NR is the most efficient means to boost NAD.”

1. Demonstrated in animal in-vitro studies.

2. Demonstrated in an in-vivo mouse study.

3. Trammell, S. A., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., . . . Brenner, C. (2016). Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications, 7, 12948. doi:10.1038/ncomms12948

Where do I find NR?