Manipulating biosynthesis pathways may hold promise for preventing chemotherapy-induced pain

Researchers at the University of Iowa and Oregon Health & Science University have found a way to prevent nerve damage caused by chemotherapy drugs. The approach bypasses a biochemical pathway that produces an important energy molecule and suggests a strategy for treating pain caused by some chemotherapy drugs.

Many anti-cancer drugs damage nerve fibers and cause severe and persistent pain known as chemotherapy-induced peripheral neuropathy (CIPN), which can decrease the quality of life for cancer patients and survivors.

The new study focuses on a set of biochemical pathways that are critical for the survival of nerves. In particular, these pathways are involved in producing and maintaining levels of a molecule called nicotinamide adenine dinucleotide (NAD), a central regulator of cell metabolism.

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2018-10-11T07:39:28-08:00 October 11th, 2018|