Published in Human & Experimental Toxicology.

Nicotimamide riboside (NR) is a naturally occurring form of vitamin B3, present in trace amounts in some foods. As with niacin, it has been shown to be a precursor to the formation of NAD. The safety of Niagen®, a synthetic form of NR, was determined in multiple studies. Both lab (“test tube”) and 14-day and 90-day toxicology studies using rats have been conducted.

NR will not cause genetic damage. It did not result in death at doses as high as 5000 mg per kg of body weight per day (mg/kg/day). The 90-day rat study compared NR at dosages of 300, 1000 and 3000 mg/kg/day with 1260 mg/kg/day of another form of niacin, nicotinamide. The doses were taken by mouth, after which researchers examined the toxicity levels in the rats’ livers, kidney, ovaries and testes.

At the highest dose tested, results showed that NR has a similar toxicity profile to nicotinamide. The lowest dose of NR at which researches observed an adverse effect was 1000 mg/kg/day. There were no observed adverse effects at 300 mg/kg/day.

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